The Vatican confirmed Saturday the pope will begin the visit in Mexico City on Feb. 12, where he will say Mass at the Basilica of Guadalupe the next day.
The Pope also confirmed he will visit the Basilica of Our Lady of Guadalupe on February 13.
Mexican Cardinal Norberto Rivera said recently that the pope would arrive Feb. 12, but that date has not been confirmed by the Vatican.
Mexican retailer and bottling company Femsa said in September it was considering expanding its business to Cuba and cement maker Cemex is making similar noises.
The presidents of Mexico and Cuba announced new accords and closer political ties after more than a decade of chilly relations.
Castro was scheduled to arrive in the Yucatán peninsula city of Mérida late Thursday and meet with his Mexican counterpart, Enrique Peña Nieto, on Friday.
Vatican spokesman Federico Lombardi announced that Pope Francis will travel to Mexico next year.
"Those ringing words continue to inspire us today," he said of the Declaration of Independence.
The pope is expected to urge U.S. to take better care of the environment and the poor and return to its founding ideals of religious liberty and open arms toward immigrants.
Francis is the third pontiff to visit Cuba in 17 years.