He met with the young and the old, the powerful and the weak.
Francis says the world can build peace from its differences.
Francis also asserted that the world's poor have a right to education, lodging, labor and land.
Francis, the son of Italian immigrants to Argentina, recalled that the America itself was founded by immigrants and that many lawmakers are descended from foreigners.
Francis praised the bishops for defending the rights of migrants, helping them to prosper and keeping their faith alive.
His criticism of unbridled capitalism has unsettled U.S. conservatives.
The pope is expected to urge U.S. to take better care of the environment and the poor and return to its founding ideals of religious liberty and open arms toward immigrants.
He noted that it is a tradition among the popes to condemn the blockade.
Santiago is the last stop on the Pope's tour of the island.
The Pontiff spoke before young Cubans.